Enantioselective Synthesis of Pactamycin, a Complex Antitumor Antibiotic
نویسندگان
چکیده
منابع مشابه
Enantioselective synthesis of pactamycin, a complex antitumor antibiotic.
Medicinal application of many complex natural products is precluded by the impracticality of their chemical synthesis. Pactamycin, the most structurally intricate aminocyclopentitol antibiotic, displays potent antiproliferative properties across multiple phylogenetic domains, but it is highly cytotoxic. A limited number of analogs produced by genetic engineering technologies show reduced cytoto...
متن کاملEnantioselective Synthesis of Modafinil Drug using Chiral Complex of Titanium and Diethyltartarate
Modafinil (Diphenyl methyl Sulfinyl acetamid) is used clinically in the treatment of narcolepsy and sleeping disorders. The synthesis of R-modafinil, have started with the reaction of benzhydrol and thioglycolic acid in trifluoroacetic acid to afford benzhydryl sulfanyl acetic acid. The reaction of acid with thionyl chloride in benzene followed by treatment with ammonium hydroxide gave acetamid...
متن کاملChemoenzymatic Enantioselective Formal Synthesis of (-)-Gephyrotoxin-223
(-)-Gephyrotoxin-223 was formally synthesized from chiral synthon 1 which has been chemoenzymatically synthesized in the presence of Candida Antartica lipase.
متن کاملA New Antitumor Antibiotic
In the course of our screening program we have isolated from the culture fo Actinomadura carminata carminomycin, a new anthracycline antibiotic which possessed strong antitumor activity in animal experiments. It is produced as a mixture of several active components: the more interesting ones are components 1, 2 and 3. Components 2 and 3 can be transformed by means of mild hydrolysis into carmin...
متن کاملThe total synthesis of spergualin, an antitumor antibiotic.
Sir: During our studies of antitumor antibiotics, spergualin was discovered in culture filtrates of a Bacillus strain.') Spergualin showed a marked inhibition against experimental mouse tumors, and the structure was determined to be (-)(I 5S)-1-aminol9-guanidino-11,15-dihydroxy-4, 9,12-triazanonadecane-10,13-dione2>. In thiscommunication, we report the synthesis of epimeric spergualin (1) and e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 2013
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1234756